Abstract: Most human characteristics change over time. By recording them repeatedly we can obtain trajectories of these changes. Currently, most studies of the genetic factors underlying human disease only consider these characteristics at a single time point and ignore how genetics affect the pattern of change, which would likely be a better prognostic measure of disease.
However, there are no analytical and computational tools that can perform such complex statistical analyses in very large studies to make meaningful epidemiological inferences. The project will aim to develop and apply these tools for the analyses of large-scale cohorts such as UK Biobank.